Loes Research Lab

About Us

We study the genetics of severe mental illness. Specifically, we aim to characterize and predict psychiatric disease trajectories using genetic and high-dimensional phenotypic data resources, such as electronic health records. We have a special focus on studying genetic and environmental risk factors that contribute to the cause and course of illness in admixed populations, in Colombia, Brazil and the USA. Through Misión Origen, we are creating a biobank for Severe Mental Illness, consisting of 100,000 participants from the Paisa region of Colombia.

We are a research group in the Center for Neurobehavioral Genetics in the Department of Psychiatry and Biobehavioral Sciences in the Semel Institute of the David Geffen School of Medicine at UCLA. We are also affiliated with the Departments of Human Genetics and Computational Medicine and the Bioinformatics, and Biomath PhD programs.

Funded by:  NIH  |  Amazon | BD2 | GP2

News

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Transdiagnostic characterisation and co-occurrence of clinical features extracted from EHR notes.
Article

New paper alert!

Characterisation of serious mental illness trajectories through transdiagnostic clinical features

1 min read
Schematic depiction of the development and evaluation of the NLP algorithms.
Article

New paper alert!!

Leveraging NLP for Psychiatric Phenotyping from Spanish EHR: Enabling the Investigation of Transdiagnostic Symptom Profiles at Scale

1 min read