We are a research group in the Center for Neurobehavioral Genetics in the Department of Psychiatry and Biobehavioral Sciences in the Semel Institute part of the David Geffen School of Medicine at UCLA, and Computational Medicine. We are also affiliated with the Bioinformatics, Human Genetics and Medical Informatics PhD programs.
We study the genetics of severe mental illness. Specifically, we aim to characterize and predict psychiatric disease trajectories using genetic and high-dimensional phenotypic data resources, such as electronic health records. We have a special focus on studying genetic and environmental risk factors that contribute to the cause and course of illness in admixed Latin American populations. Through Misión Origen, we are creating a biobank for Severe Mental Illness, consisting of 100,000 participants from the Paisa region of Colombia.
We are funded by:
The Loes lab is finally back on campus!
NEW PAPER: We studied the genetics of onset characteristics of bipolar disorder; out now! The bottom line: phenotypic heterogeneity made this genetic study really complicated, and interesting too. It was amazing to work with so many devoted PGCgenetics researchers on this. Check it out!
Check out Juan de la Hoz in the Semel trainee spotlight!
We loved hosting two amazing students for BIG summer this year: Julia Bowers and Benjamin Simon! They used clinical notes to cluster psychiatric patients and won the outstanding research award! Juan de la Hoz was their direct mentor and won both the award for outstanding mentorship and outstanding TA-ship.
What a summer! Congrats Julia, Benjamin and Juan!!