Welcome to the Loes Lab!

We are a research group in the Center for Neurobehavioral Genetics in the Department of Psychiatry and Biobehavioral Sciences in the Semel Institute of the David Geffen School of Medicine at UCLA. We are also affiliated with the Departments of Human Genetics and Computational Medicine and the Bioinformatics, Human Genetics and Medical Informatics PhD programs.

We study the genetics of severe mental illness. Specifically, we aim to characterize and predict psychiatric disease trajectories using genetic and high-dimensional phenotypic data resources, such as electronic health records. We have a special focus on studying genetic and environmental risk factors that contribute to the cause and course of illness in admixed Latin American populations. Through Misión Origen, we are creating a biobank for Severe Mental Illness, consisting of 100,000 participants from the Paisa region of Colombia.

We are funded by:

NIMH logo
 

News

  •  
  •  

    NEW PREPRINT: We used Electronic Health Records from Caldas, Colombia to characterize geographic variation in major mental disorders.

     

    We found a relationship of distance decay between travel time and the incidence for mild (outpatients) but not severe (inpatients) presentations of mental illness. We also found several hotspots of severe mental illness in the region. This is exciting, since each hotspot is a candidate for further research to identify genetic or environmental risk factors for severe mental illness.

    Check it out!

     

     

    March 25, 2022
  •  

    We welcome Aditya Pimplaskar as an official lab member! Aditya is doing his PhD in Bioinformatics and will work on developing tools to cluster patients with similar trajectories. Welcome Aditya!

     

    March 10, 2022
  •  

    The Loes lab is finally back on campus!

     

    September 30, 2021
  •  

    NEW PAPER: We studied the genetics of onset characteristics of bipolar disorder; out now! The bottom line: phenotypic heterogeneity made this genetic study really complicated, and interesting too. It was amazing to work with so many devoted PGCgenetics researchers on this. Check it out!

     

    August 25, 2021
  •  

    Check out Juan de la Hoz in the Semel trainee spotlight!

     

    August 21, 2021
  •  

    We loved hosting two amazing students for BIG summer this year: Julia Bowers and Benjamin Simon! They used clinical notes to cluster psychiatric patients and won the outstanding research award! Juan de la Hoz was their direct mentor and won both the award for outstanding mentorship and outstanding TA-ship.

     

    What a summer! Congrats Julia, Benjamin and Juan!!  

    August 20, 2021
  •  
    We had our first lab outing to Will Rogers State Park! (Physically distanced and mostly vaccinated)

    April 8, 2021
  •  
    Jonathan Valdez joined our lab as a research coordinator for Misión Origen. Welcome Jonathan!

    April 8, 2021
  •  
    We started recruitment for Misión Origen! Here is the amazing team. 

    Jan 23 2021
  •  
    We launched our website!

    Jan 18 2021